This happens if you have the 32-bit version of the Visual Studio runtime files, but not the 64-bit version. When you download and extract the 64-bit version of Pencil2D, there is a file called vc_redist.exe you need to run. This will install the necessary missing components. After that, the 64-bit version of Pencil2D should work fine on your computer. See here if you want some more details: VCRUNTIME140_1.dll / MSVCP140.dll Missing? Help.