@Dragntail Hi. This is most likely a windows issue and not a Pencil2D issue. You need to make sure of the following:
- You are using the appropriate bit architecture version (e.g 32bit o 64bit)
- You are using the appropriate Pencil2D version for your Windows version (e.g legacy: Windows XP, Windows 7, Modern: Windows 10)
- You have your Windows installation up to date via windows update.
- You need to install the Microsoft Redistributables and missing components as mentioned in the following threads:
VCRUNTIME_140.dll / Windows 10
MSVCP140.DLL / Windows 8 and under + Universal C Runtime
Lastly I found this guide to follow which seems sensible enough: