@JTempest Hi. If you’re using Windows, particularly Windows 10 along the latest Wacom drivers downloaded from their support site there are some extra steps you could take for Pencil2D to work please take a look at the following reply which is in itself a guide with tips to address issues with Wacom tablets:
If you are using macOS i’m afraid only a few of those tips will be useful, and if you try to restart the service take a look at this OS specific guide: Restarting Your Wacom Services Driver - 'Tablet Driver Not Found' – MacHollywood | Your Premier Tech Partner