@zachcantwelltv Hey. For maximum compatibility please download the latest Nightly Build, don’t use the download version 0.5.4b. If you don’t know where to get it just visit the download section of our static page at Http://pencil2d.github.io
If you use a Wacom tablet it will work right out the box. The Pencil tool is a bit faulty right now as it needs about 50% of strenght to start working, but the Pen tool works like a charm.
If you’re planning on purchasing a screen tablet like a cintiq or a similar product, i’m afraid that I can’t say if it works or not properly. Some people have said it does some others have had issues, but this relates to your screen calibration and this mainly relates to how you install and configure your drivers, but we have no way to help with individual consumer hardware installation that since there are too many variables to consider and that’s what manuals are for.
Bottom line, if you install your tablet drivers and do all the required procedures, not only Pencil2D will work, but any other drawing program will work. It usually boils down to your computer configuration and your OS choice.
For example I use Windows 7 with an Intuos 5 Pro and it works great so far. Hope this helps to clear your doubts.
p.s. If all fails you can use Krita too.